Gambaran Histopatologi Duodenum Dengan Diinduksi Aspirin® Dan Pemberian Ekstrak Daun Widuri (Calotropis gigantea) Pada Tikus Putih (Rattus norvegicus)

Atok, Yunita (2020) Gambaran Histopatologi Duodenum Dengan Diinduksi Aspirin® Dan Pemberian Ekstrak Daun Widuri (Calotropis gigantea) Pada Tikus Putih (Rattus norvegicus). Bachelor (S1) thesis, Wijaya Kusuma Surabaya University.

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Abstract

This research aimed to determine the overview of duodenum histopathology that contained necrosis, degeneration and inflamed-cell infiltration in duodenum muccose that inducted by aspirin and widuri leaves (Calotropis gigantea) ekstract in white rat (Rattus norvegicus). The experimental animals that used in this research were 25 white rats that selected by simple random sampling technic. The design that used in this research was complete random design that devided into 5 groups of treatment and 5 repetition in each groups. The treatment group were P0 = negative control group, P1 = positive control group that gave aspirin 500 mg/kg body weight, P2 = was the group that given aspirin 500 mg/kg body weight and widuri leaves extract 50 mg/kg body weight, P3 = was the group that given aspirin 500 mg/kg body weight and widuri leaves extract 100 mg/kg body weight, P4 = was the group that given aspirin 500 mg/kg body weight and widuri leaves extract 150 mg/kg body weight. Data that collected analyzed by Kruskal-Wallis statistic test and Mann-Whitney Test. Based on the by Kruskal-Wallis Test and Mann-Whitney Test, p (Asymp.sig) < 0.05. That means there was the real different between groups of treatments. The conclusion of this research was the dosis 100 mg/kg body weight dan 150 mg/kg body weight dose of widuri leaves extract could decrease the duodenum necrosis in P3 with a score of 2.60 and P4 with a score 1.40, degeneration in P3 with a score 0.60 and P4 with a score 0.00 and inflammation in P3 with a score 1.00 and P4 with a score 1.20.

Item Type:	Thesis (Bachelor (S1))
Uncontrolled Keywords:	Histopathology overview, Widuri Leaves Extract, Aspirin, White Rat
Subjects:	R Medicine > RB Pathology
Divisions:	Faculty of Vetenary Medicine > Animal Health and Veteriner Public Health Study Program
Depositing User:	Yunita Atok
Date Deposited:	16 Mar 2020 03:36
Last Modified:	16 Mar 2020 03:36
URI:	http://erepository.uwks.ac.id/id/eprint/6281

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