Gambaran histopatologi ginjal yang diberikan ekstrak daun widuri (Calotropis gigantea) dan diinduksi aspirin® terhadap tikus putih (Rattus norvegicus)

Bele, Alexander Joharry Leto (2019) Gambaran histopatologi ginjal yang diberikan ekstrak daun widuri (Calotropis gigantea) dan diinduksi aspirin® terhadap tikus putih (Rattus norvegicus). Bachelor (S1) thesis, Wijaya Kusuma Surabaya University.

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Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui gambaran histopatologi nekrosis, degenerasi dan infiltrasi sel radang pada ginjal yang diinduksi aspirin dan ekstrak daun widuri (Calotropis gigantea) pada tikus tikus putih (Rattus norvegicus). Hewan coba yang digunakan adalah tikus putih sebanyak 25 ekor yang dipilih dengan menggunakan teknik Simple Random Sampling. Rancangan yang digunakan adalah rancangan acak lengkap dengan 5 kelompok perlakuan dan 5 ulangan. Kelompok perlakuan tersebut adalah P0 = kelompok kontrol negatif, P1 = kelompok kontrol positif dengan pemberian aspirin 500 mg/kg BB, P2 = Kelompok pemberian aspirin dosis 500 mg/kg BB dan ekstrak daun widuri dosis 50 mg/kg BB, P3 = Kelompok pemberian aspirin dosis 500 mg/kg BB dan ekstrak daun widuri dosis 100 mg/kg BB, P4 = Kelompok pemberian aspirin dosis 500 mg/kg BB dan ekstrak daun widuri dosis 150 mg/kg BB. Data yang diperoleh dianalisis menggunakan uji statistic Kruskal-Wallis dan dilanjutkan dengan uji Mann-Whitney Test. Berdasarkan hasil perhitungan uji statistik Kruskal-Wallis dan uji Mann-Whitney Test nilai p (Asymp.sig) <0.05 yang artinya terdapat perbedaan yang nyata antara kelompok kontrol dan perlakuan. Dari hasil penelitian diperoleh kesimpulan bahwa pemberian ekstrak daun widuri dengan dosis 100 mg/kg BB dan 150 mg/kg BB dapat mengurangi nekrosis, degenerasi dan radang pada organ ginjal. Kata Kunci : Gambaran Histopatologi, Ekstrak Daun Widuri, Aspirin, Tikus Putih ABSTRACT This research aimed to determine the overview of gastric histopathology that contained necrosis, degeneration and inflamed-cell infiltration in gastric muccose that inducted by aspirin and widuri leaves (Calotropis gigantean) ekstract in white rat (Rattus norvegicus). The experimental animals that used in this research were 25 white rats that selected by simple random sampling technic. The design that used in this research was complete random design that devided into 5 groups of treatment and 5 repetition in each groups. The treatment group were P0 = negative control group, P1 = positive control group that gave aspirin 500 mg/kg body weight, P2 = was the group that given aspirin 500 mg/kg body weight and widuri leaves extract 50 mg/kg body weight, P3 = was the group that given aspirin 500 mg/kg body weight and widuri leaves extract 100 mg/kg body weight, P4 = was the group that given aspirin 500 mg/kg body weight and widuri leaves extract 150 mg/kg body weight. Data that collected analyzed by Kruskal-Wallis statistic test and Mann-Whitney Test. Based on the by Kruskal-Wallis Test and Mann-Whitney Test, p (Asymp.sig) < 0.05. That means there was the real different between groups of treatments. The conclusion of this research was the dosis 100 mg/kg body weight dan 150 mg/kg body weight dose of widuri leaves extract could decrease the gastric necrosis, degeneration and inflammation in kidney. Key words : Histopathology overview, Widuri Leaves Extract, Aspirin, White Rat

Item Type:	Thesis (Bachelor (S1))
Uncontrolled Keywords:	Kata Kunci : Gambaran Histopatologi, Ekstrak Daun Widuri, Aspirin, Tikus Putih Key words : Histopathology overview, Widuri Leaves Extract, Aspirin, White Rat
Subjects:	R Medicine > RB Pathology
Divisions:	Faculty of Vetenary Medicine > Animal Health and Veteriner Public Health Study Program
Depositing User:	Alexander J. Leto Bele
Date Deposited:	09 Aug 2019 06:53
Last Modified:	09 Aug 2019 06:53
URI:	http://erepository.uwks.ac.id/id/eprint/4101

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