Phycocyanin Ameliorate Trophoblast Apoptosis 1n Il-6-Induced Preeclamptic Rat Models

Gondo, Harry K and Kusworini, H and Arsana, W and Sarjoto, T W (2017) Phycocyanin Ameliorate Trophoblast Apoptosis 1n Il-6-Induced Preeclamptic Rat Models. International Journal of Pharmacognosy and Phytochemical Research, 9 (3). pp. 424-427. ISSN 0975-4873

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Abstract

Preeclampsia/eclampsia is the leading causes in maternal death. At the molecular study, pre-eclampsia caused by inadequate trophoblast invasion to endometrium. However, until now, it has no adequate medical preventive for preeclampsia. It is disease sometimes called as "disease of theory" for lack knowledge in basic molecular pathomechanism. Some study report trophoblast apoptosis is pivotal role in preeclampsia which increased lead to insufficiency trophoblast cell invasion into endometrium. Spirulina arthrospira plant or also called blue-green algae which is in the historical record has been consumed since the days of the Aztec tribe. Several studies have proven that Spirulina have the immunomodulation properties stimulate various immune functions such as production of cytokines, chemokines and other anti-inflammatory mediators. Its active bioactive Phycocyanin (PC) has been shown have an effect as anti-inflammatory and antioxidant and prevent preeclampsia occurrence in rat models through reducing pro-inflammatory cytokines However, there are no information its role in apoptotic trophoblast. Hence, this study aim to answer PC role in apoptotic trophoblast in preeclampsia rat. Methods. This research is an experimental laboratory research with post test only group design. We used rat models with preeclampsia pregnant condition induced by IL-6. To get the same rat gestational age (homogeneous) then as many as 30 female white rats do estrusnya cycle synchronization. To make a model of preeclampsia of pregnant rats, IL-6 is used in10 days post mating for 5 days at dose 5 ng/100 g/day body weight intra tail vein Result. PC has proved reducing preeclamptic trophoblast apoptosis in pregnant rats models induced by IL-6 at dose of 40 n/100 kg weight. Conclusion. This study confirm that PC has a protective effect on pregnant rats preeclampsia through its inhibiton of trophoblast apoptosis.

Item Type:	Article
Uncontrolled Keywords:	preeclampsia; apoptosis; phycocyanin; IL-6; immunofluorescence; rat trophoblast.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	19 Oct 2018 07:00
Last Modified:	19 Oct 2018 07:00
URI:	http://erepository.uwks.ac.id/id/eprint/2876

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