Kajian Peran Gen P53 Dalam Tumorigenesis

Yunani, Retina (2016) Kajian Peran Gen P53 Dalam Tumorigenesis. Jurnal Vitek, VI (2). pp. 11-16. ISSN 997-240-977002

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Abstract

Gene p53 is a tumor suppressor gene that in normal conditions is in ' standby ' mode , several studies show that pivotal point that lead to stimulation of p53 is DNA damage , heat shock , hypoxia, exposure of nitric oxide ( NO ) , the expression of oncogenes and some p53 pathways activation. p53 mechanism as a guardian of genome stability are cell cycle arrest, repair of DNA damaged, induce apoptosis, prevents angiogenesis , invasion and metastasis ability of the tumor. On many tumor , p53 is not loss , but mutated , the p53 mutant was expressed 70 % in lung cancer , and in different frequencies in other cancers . Then the role of p53 as a transcription factor that works to regulate genes involved in tumor suppression is indispensable .

Item Type:	Article
Uncontrolled Keywords:	Gene p53, Nitric oxide, DNA
Subjects:	S Agriculture > SF Animal culture
Divisions:	Faculty of Vetenary Medicine > Vetenary Education Study Program
Depositing User:	Sulimin BP3
Date Deposited:	18 Oct 2018 01:50
Last Modified:	18 Oct 2018 01:50
URI:	http://erepository.uwks.ac.id/id/eprint/2866

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