Perbedaan Efektivitas Anastesi Kombinasi Atropin, Xylazin, dan Ketamin terhadap Mula dan Lama Kerja Obat Tikus Putih (Rattus norvegicus) berdasarkan Rute Injeksi yang Berbeda.

Lutfi, Achmad (2026) Perbedaan Efektivitas Anastesi Kombinasi Atropin, Xylazin, dan Ketamin terhadap Mula dan Lama Kerja Obat Tikus Putih (Rattus norvegicus) berdasarkan Rute Injeksi yang Berbeda. [Tugas Akhir/Skripsi] (Unpublished)

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Abstract

Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas kombinasi anestesi atropin, xilazin, dan ketamin terhadap waktu awal kerja (onset of action) dan durasi kerja pada tikus putih (Rattus norvegicus) berdasarkan lokasi penyuntikan yang berbeda. Penelitian ini merupakan studi eksperimental laboratorium yang menggunakan Rancangan Acak Lengkap (RAL), dengan melibatkan 24 ekor tikus putih Wistar jantan berusia 2–3 bulan dan berbobot badan 200–300 gram. Hewan coba dibagi menjadi empat kelompok: kelompok kontrol menerima akuades melalui jalur intraperitoneal (IP), kelompok P1 menerima kombinasi atropin, xilazin, dan ketamin melalui jalur intraperitoneal (IP), kelompok P2 melalui jalur intramuskular (IM), dan kelompok P3 melalui jalur subkutan (SC). Parameter yang diamati meliputi waktu awal kerja dan durasi kerja, yang diukur menggunakan stopwatch dan lembar observasi. Data dianalisis menggunakan ANOVA yang dilanjutkan dengan uji Duncan pada tingkat kepercayaan 95%. Hasil penelitian menunjukkan adanya perbedaan yang signifikan (P≤0,05) pada waktu awal kerja dan durasi kerja di antara kelompok-kelompok perlakuan tersebut. Jalur intramuskular (IM) menghasilkan waktu awal kerja tercepat, dengan rata-rata 3,17 ± 1,722 menit, serta durasi kerja terlama, dengan rata-rata 134,83 ± 31,346 menit. Jalur subkutan (SC) menghasilkan waktu awal kerja 6,33 ± 1,211 menit dan durasi kerja 67,17 ± 31,070 menit, sedangkan jalur intraperitoneal (IP) menghasilkan waktu awal kerja paling lama, yaitu 12,17 ± 3,371 menit, dan durasi kerja paling singkat, yaitu 59,83 ± 16,092 menit. Berdasarkan hasil tersebut, dapat disimpulkan bahwa rute intramuskular (IM) merupakan rute pemberian paling efektif untuk kombinasi atropin, xilazin, dan ketamin pada tikus putih karena menghasilkan onset anestesi tercepat dan durasi anestesi terlama. =============================================================== This study aimed to determine the differences in the effectiveness of the anesthetic combination of atropine, xylazine, and ketamine on the onset of action and duration of action in white rats (Rattus norvegicus) based on different injection sites. This research was a laboratory experimental study using a Completely Randomized Design (CRD), involving 24 male Wistar white rats aged 2–3 months with body weights of 200–300 grams. The experimental animals were divided into four groups: the control group received distilled water via the intraperitoneal (IP) route, group P1 received the combination of atropine, xylazine, and ketamine via the intraperitoneal (IP) route, group P2 via the intramuscular (IM) route, and group P3 via the subcutaneous (SC) route. The observed parameters included onset of action and duration of action, measured using a stopwatch and observation sheet. The data were analyzed using ANOVA followed by Duncan’s test at a 95% confidence level. The results showed significant differences (P≤0.05) in onset of action and duration of action among the treatment groups. The intramuscular (IM) route produced the fastest onset of action, with an average of 3.17 ± 1.722 minutes, and the longest duration of action, with an average of 134.83 ± 31.346 minutes. The subcutaneous (SC) route produced an onset of action of 6.33 ± 1.211 minutes and a duration of action of 67.17 ± 31.070 minutes, while the intraperitoneal (IP) route produced the longest onset of action, at 12.17 ± 3.371 minutes, and the shortest duration of action, at 59.83 ± 16.092 minutes. Based on the results, it can be concluded that the intramuscular (IM) route is the most effective administration route for the combination of atropine, xylazine, and ketamine in white rats because it produces the fastest anesthetic onset and the longest anesthetic duration.

Item Type:	Tugas Akhir/Skripsi
Uncontrolled Keywords:	Kata kunci: atropin, xilazin, ketamin, onset kerja, durasi kerja, tikus putih. =============================================================== Keywords: atropine, xylazine, ketamine, onset of action, duration of action, white rats.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Vetenary Medicine > Vetenary Education Study Program
Depositing User:	82 Achmad Lutfi UWKS
Date Deposited:	30 Sep 2026 03:11
Last Modified:	30 Sep 2026 03:11
URI:	http://erepository.uwks.ac.id/id/eprint/23962

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