Pengaruh Pemberian Ekstrak Buah Pare Terhadap Kadar TNF- α Pada Kultur Sel Trofoblas Suasana Hiperglikemia

Bi'arsyihah, Ninda Tsalitsa Nisya'u (2024) Pengaruh Pemberian Ekstrak Buah Pare Terhadap Kadar TNF- α Pada Kultur Sel Trofoblas Suasana Hiperglikemia. [Tugas Akhir/Skripsi] (Unpublished)

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Abstract

Pregnant women are particularly vulnerable to gestational diabetes mellitus. Generally, patients with gestational diabetes mellitus are also found to have inflammatory reactions due to the ease of infection. The purpose of this study was to analyze TNF-α levels in pregnant women with hyperglycemia conditions after being given bitter melon extract to trophoblast cells. This research is a laboratory experimental research with a Control Group Post Test Design research design, using the RAL method, The sample of this study was trophoblast cells who underwent delivery by the Section Caessaria method in physiological pregnancy conditions. The research process was carried out by culturing and isolating trophoblast cells, by chopping the trophoblast cells into 6 parts, namely K-; K+; Doses A, BC, and treat each trophoblast cell with glucose at a dose of 33 mm and bitter melon extract at a dose of 0.1, 0.2, 0.4, 0.8 respectively. Data analysis was carried out using the One Way Annova statistical test. The research results show that there is an effect of administering bitter melon fruit extract on TNF-α levels in trophoblast cells obtained from cultured human placentas and isolated trophoblast cells. This is proven by the p value of 0.001, namely < α (0.05). Giving bitter melon fruit extract at doses of (0.1), (0.2), (0.4), (0.8) to each group of trophoblast cells was able to suppress the increase in TNF-α so that the levels in dose groups A, B , C, D had lower levels of TNF- α than the positive group

Item Type:	Tugas Akhir/Skripsi
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	ninda tsalitsa nisya'u bi'arsyihah
Date Deposited:	27 Aug 2024 03:32
Last Modified:	27 Aug 2024 03:32
URI:	http://erepository.uwks.ac.id/id/eprint/18489

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