Studies on microRNA in Pediatric Tuberculosis

Sanjaya, Ayling (2020) Studies on microRNA in Pediatric Tuberculosis. Systematic Reviews in Pharmacy. (Unpublished)

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Abstract

Background: Pediatric tuberculosis (TB) is still a major problem in the world leads to adverse complications. Research of microRNA(miRNA) conducted to study and identify specific miRNA expression among active TB children specifically in Indonesia. This suggests that miRNA can be one of the diagnostic tools and therapy for pediatric TB that needs to be developed. Aims: To study spesific miRNA expression in pediatric active TB in Indonesia using microarray profiling. Methods: This research was an observational analytic study using a cross sectional study design. The study used whole blood of healthy control children who had never received BCG immunization and children diagnosed with active TB. Identified miRNAs expression profile with microarray analysis. Results: Four Active TB and 2 healthy control children were included in this study. Extraction of RNA with whole blood were done and profiled with microarray methods. Fold change >2 or <-2 with p-val <0.05. Expression of miRNA passed filter criteria are 251 miRNA with 30 (11.95%) miRNA up-regulated and 221 (88.05%) miRNA down-regulated. Conclusions: Our study suggests that there are a specific miRNAs identified in active TB children in Indonesia and can be one of the tools to diagnosis and monitoring of therapy that needs to be developed. Keywords: microRNA, pediatric, tuberculosis

Item Type:	Other
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	05 Dec 2022 13:55
Last Modified:	05 Dec 2022 13:55
URI:	http://erepository.uwks.ac.id/id/eprint/13260

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