Interleukin-8 (IL-8) Role in Children with Dengue Hemorrhagic Fever

Sanjaya, Ayling (2019) Interleukin-8 (IL-8) Role in Children with Dengue Hemorrhagic Fever. Indian Journal of Public Health Research & Development. (Unpublished)

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Abstract

Background: Dengue hemorrhagic fever (DHF) is an infectious disease caused by dengue virus and still become a health problem in Indonesia. Interleukin-8 (IL-8) has been widely accepted as a factor correlated with severity of DHF. However, its role in Dengue Haemmorhhagic Shock Syndrome (DHSS) was still poorly understood. This study was conducted to elucidate correlation of IL-8 and DHSS in children. Objective: To determine the correlation between IL-8 and DHF in children. Methods: We conducted across sectional study in pediatric ward general hospital of Prof.Dr.R.D.Kandou Manado in March until August 2011. Fourty children aged 1-13 years old was conducted consecutively and divided in to shock and without shock DHF. IL-8 was examined in each group and the correlation with DHF was analyzed with Spearman rho test using SPSS software withP<0.05. Result: The mean of IL-8 level in DHF children without shock was 45.63 (95% CI 31.88 to 59.37) ng/ml and in DHF with shock was 411.13 (95% CI 311.46 to 510.80) ng/ml. The correlation between IL-8 and DHF was staticticaly significant (rs = 0,774 , p<0.001). Conclusions: The IL-8 level in DHF in these two groups were increase, and higher in severe DHF (with shock). Higher level of IL-8 correlated with increasing severity of DHF. Keywords: IL-8; DHF; children, interleukin, hemorrhagic fever

Item Type:	Other
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	05 Dec 2022 13:56
Last Modified:	05 Dec 2022 13:56
URI:	http://erepository.uwks.ac.id/id/eprint/13252

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