Efektivitas Ekstrak Daun Salam (Eugenia polyantha) Menurunkan Kadar Malondialdehyde Pada Kondisi Tikus Hiperlipid

Tania, Putu Oky Ari (2021) Efektivitas Ekstrak Daun Salam (Eugenia polyantha) Menurunkan Kadar Malondialdehyde Pada Kondisi Tikus Hiperlipid. Universitas Tribhuwana Tunggadewi. (Unpublished)

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Abstract

ABSTRACT Phenomenon of consuming fast food which is high in fat is increasing in urban communities. A high-fat diet leads to increasing intake of fatty acid in liver, making it susceptible to lipid peroxidation and free radical release. Malondialdehyde is a common biomarker for lipid peroxidation. Increasing free radicals should be balanced with the antioxidants in order to prevent oxidative stress. This study aim was to measured the effectiveness of bay leaf extract (Eugenia polyantha) in lowering MDA levels in hyperlipidemia rats. This study was an experimental study using 20 male rats divided into 4 groups; KP, KN, P1 and P2. All rats were induced hyperlipidemia with high-fat diet for 12 days. KP was sacrificed in the next day after the feeding of high fat. KN administered by aquades 2 ml / day (peroral / po), P1 administered by bay leaves extract 1.08 g / day (p.0) and P2 received simvastatin treatment dose 0,0018 g / 150 g BB / day (p. 0). The results showed MDA levels in KP, KN, P1 and P2 were respectively 7.79; 7.07; 6.49; and 7.21 nmol / ml. One way ANOVA test showed p value was 0,073 (<0,05) so there was no effect of effectiveness of bay leaf in lowering MDA level compared to simvastatin and aquades. Oxidative stress conditions due to a high-fat diet can be recovered when the diet was stopped. For this reason, it is recommended for further research that the administration of drug treatment can be combined with a high-fat diet so that the effect of reducing oxidative stress can be observed. Keywords : bay leaf, high-fat diet, MDA

Item Type:	Other
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	23 Sep 2022 05:42
Last Modified:	23 Sep 2022 05:42
URI:	http://erepository.uwks.ac.id/id/eprint/12466

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