Gambaran histopatologi ginjal yang diinduksi gentamisin dan pemberian tepung buah jambu biji merah (psidium guajava l.) pada tikus putih (rattus norvegicus)

Latif, Annisa Catria (2019) Gambaran histopatologi ginjal yang diinduksi gentamisin dan pemberian tepung buah jambu biji merah (psidium guajava l.) pada tikus putih (rattus norvegicus). Bachelor (S1) thesis, Wijaya Kusuma Surabaya University.

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Abstract

Gentamicin is an aminoglycoside antibiotic used to treat serious gram negative bacterial infections. Side effects of Gentamicin can induce nephrotoxicity associated with Acute Kidney Injury (AKI) due to acute tubular necrosis. This is related to the formation of free radicals induced by Gentamicin which cause oxidative damage. Red Guava (Psidium guajava L.) contains high antioxidants such as vitamin C 69.6mg/100g which can compensate for free radicals and protect the kidneys from damage. This study aims to analyze the histopathology of white rats’ kidney given red guava fruit flour after administration of Gentamicin. This study was an experimental study using 24 white rats divided into 4 groups. The P0 group was the control group, while the groups P1, P2 and P3 were the treatment group given Gentamicin 60mg/kgBW I.M for 7 days. After being given Gentamicin, P1 group was given aquades P.O, P2 was given red guava fruit flour 1g/kgBW P.O and P3 was given synthetic vitamin C 1g/kgBW P.O, then terminated on day-15. The results showed that red guava flour could reduce the nephrotoxic gentamicin effect seen from tubular epithelial cell necrotic and degeneration lesion (P<0.05), whereas in inflammatory cell infiltration lesions the results were not significantly different (P>0.05).

Item Type: Thesis (Bachelor (S1))
Subjects: R Medicine > RC Internal medicine
R Medicine > RZ Other systems of medicine
Divisions: Faculty of Vetenary Medicine
Depositing User: Annisa Catria Latif
Date Deposited: 01 Aug 2019 04:02
Last Modified: 01 Aug 2019 04:02
URI: http://erepository.uwks.ac.id/id/eprint/4051

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