Paparan Sub-Kronik 90 Hari Fermentasi Crescentia cujete L. Dosis 500 mg/kg BB Terhadap Imunoekspresi Cyclooxygenase-2 Pada Duodenum Tikus Sprague Dawley

Samalinggai, Nabilla Fareindhira (2026) Paparan Sub-Kronik 90 Hari Fermentasi Crescentia cujete L. Dosis 500 mg/kg BB Terhadap Imunoekspresi Cyclooxygenase-2 Pada Duodenum Tikus Sprague Dawley. [Tugas Akhir/Skripsi]

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Abstract

Calabash fruit (Crescentia cujete L.) contains bioactive compounds with potential biological effects; however, long-term exposure requires comprehensive safety evaluation. Repeated administration of fermented calabash fruit may influence gastrointestinal inflammatory responses, including alterations in cyclooxygenase-2 (COX-2) immunoexpression in the duodenum. The study aimed to evaluate the effect of 90-day subchronic exposure to fermented calabash fruit at a dose of 500 mg/kg body weight on COX-2 immunoexpression in the duodenum of Sprague Dawley rats. An experimental labaratory study was conducted using a 90-day subchronic toxicity design, in which Sprague Dawley rats were assigned to control and treatment groups, followed by histopathological examination and immunohistochemical analysis of COX-2 expression in duodenal tissue. The results showed that the mean percentage of COX-2 positive area was 7.63 ± 3.20% in the control group and 5.50 ± 1.27% in the treatment group, with no. statistically significant difference between groups (p>0,05). The treatment group showed a lower mean COX-2 immunoexpression compared to the control group. In conclusion, administration of fermented calabash fruit at 500 mg/kg body weight for 90 days did not increase inflammatory response in the duodenum of Sprague Dawley rats, indicating a favorable safety profile for duodenal tissue.

Item Type:	Tugas Akhir/Skripsi
Uncontrolled Keywords:	Calabash fruit, Crescentia cujete, 90-day subchronic toxicity, COX-2, duodenum
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Vetenary Medicine
Depositing User:	82 Nabilla Fareindhira Samalinggai
Date Deposited:	08 Sep 2026 06:29
Last Modified:	08 Sep 2026 06:29
URI:	http://erepository.uwks.ac.id/id/eprint/23509

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