Pengaruh pemberian vitamin D3 terhadap kadar glukosa darah tikus wistar diabetes mellitus yang diinduksi alloxan

Maulidi, Ahmad (2025) Pengaruh pemberian vitamin D3 terhadap kadar glukosa darah tikus wistar diabetes mellitus yang diinduksi alloxan. [Tugas Akhir/Skripsi]

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Abstract

Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia resulting from impaired insulin secretion or action. One of the alternative adjuvant therapies currently being developed is vitamin D, which plays a role in increasing insulin sensitivity and reducing inflammation. This study aimed to determine the effect of vitamin D3 administration on blood glucose levels in alloxan-induced diabetes mellitus Wistar rats. This was an experimental study with a pre-test and post-test control group design involving 24 male Wistar rats, divided into four groups: negative control (K-), positive control (K+), treatment 1 (P1; vitamin D3 dose 1000 IU/kgBW), and treatment 2 (P2; vitamin D3 dose 2000 IU/kgBW). Diabetes induction was performed using alloxan at a dose of 150 mg/kgBW intraperitoneally. Vitamin D3 was administered for 4 weeks. Blood glucose levels were measured before induction, after induction, and after treatment. Data were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test. The results showed significant differences in blood glucose levels among the groups (p = 0.002). Group P1 showed a decrease of 15.17 mg/dL, while group P2 showed a decrease of 56.33 mg/dL. In conclusion, vitamin D3 administration can reduce blood glucose levels in alloxan-induced diabetes mellitus Wistar rats, with a greater reduction trend at a dose of 2000 IU/kgBW. Keywords: Vitamin D3, diabetes mellitus, blood glucose, alloxan, Wistar rats.

Item Type:	Tugas Akhir/Skripsi
Uncontrolled Keywords:	Keywords: Vitamin D3, diabetes mellitus, blood glucose, alloxan, Wistar rats.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	70 Ahmad Maulidi UWKS
Date Deposited:	08 Jan 2026 04:33
Last Modified:	08 Jan 2026 04:33
URI:	http://erepository.uwks.ac.id/id/eprint/21888

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