Apsari, Ni Luh Putu Previa Niti (2023) Ekstrak Buah Pare Untuk Menurunkan Inflamasi Pada Kultur Sel Trofoblas Suasana Hiperglikemia Melalui Jalur IL-4. Bachelor (S1) thesis, Wijaya Kusuma Surabaya University.
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Abstract
Diabetes melitus (DM) merupakan gangguan metabolisme yang ditandai dan diidentifikasi dengan adanya hiperglikemia tanpa pengobatan. Etiopatologi heterogen DM meliputi defek pada sekresi insulin, kerja insulin, gangguan metabolisme karbohidrat, lemak, dan protein. Selama tahun 2019, setidaknya ditemukan sebanyak 463 juta kasus DM atau terjadi pada 9,65% penduduk dunia, khususnya pada usia 20-79 tahun. Tujuan pnelitian ini untuk mengetahui apakah ada pengaruh pemberian ekstrak buah pare untuk menurunkan inflamasi pada kultur sel trofoblas suasana hiperglikemia melalui jalur IL-4. Jenis penelitian yang digunakan dalam penelitian ini adalah eksperimental laboratorik pada kultur sel trofoblas dengan menggunakan desain penelitian Control Group Post Test Design. Populasi dalam penelitian ini adalah plasenta normal didapatkan melalui persalinan normal pervaginam atas persetujuan pasien yang diperoleh dari Rumah Sakit swasta di Surabaya. Hasil uji One Away ANOVA didapatkan bahwa nilai signifikasi (0,008). Hal ini berarti H0 ditolak dan H1 diterima sehingga dapat disimpulkan bahwa ada pengaruh pemberian ekstrak buah pare terhadap kadar IL-4 pada kultur sel trofoblas suasana hiperglikemia. Pada kelompok dosis 0,8 mg/ml memiliki nilai tertinggi dibandingkan kelompok dosis lainnya. Kesimpulan penelitian ini ada 11 pengaruh pemberian ekstrak buah pare terhadap kadar IL-4 pada kultur sel trofoblas suasana hiperglikemia. Kata kunci : DAFTAR PUSTAKA Alif Z., Hermanto TJ, Widijati. (2018). Pengaruh Insulin, Jahe, Dan Kombinasi Keduanya Terhadap Jumlah Sel Trofoblasrattus Norvegicusmodel Diabetespragestasional. Qanun Medika, 2(1), 21-28. Al-Musawi, J.F.H. (2022). The Efficacy of Momordica Charantia L. (Herbal Agent) in Treatment of Type 1 Diabetes Mellitus in Rats in Comparison to Insulin (Animal Model). International Journal of Health Sciences, 6(S3), 6061-6070. Bare, Y., Kuki, A. D., Rophi, A. H., Krisnamurti, G. C., Lorenza, M. R. W. G., & Sari, D. R. T. (2019). Prediksi Asam Kuinat sebagai Anti-inflamasi terhadap COX-2 secara Virtual. Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati, 4(3), 124-129. Cheng, D., Gao, L., Su, S., Sargsyan, D., Wu, R., Raskin, I., & Kong, A. N. (2019). Moringa isothiocyanate activates Nrf2: potential role in diabetic nephropathy. The AAPS journal, 21(2), 1-14. Dawood, A.S., & Hussein, N. (2022). Evaluation of the Role of Interleukin-4 with Doppler Studies in Pregnancy Induced Hypertension and Its relation to Fetal Outcome. GinPolMedProject, 3(63), 1-5. Firdaus, Rimbawan, Sri Anna M., Katrin R., (2016). Model Tikus Diabetes yang Diinduksi Sreptozotocin-Sukrosa untuk Pendekatan Penelitian Diabetes Melitus Gestasional. Jurnal MKMI, 12(1). 29-34. Fitri, A., Sunyoto, & Nurul H., (2016). Uji Sifat Fisik Formulasi Tablet Anti Diabetes Ekstrak Pare (Momordica Charantia L.) Dengan Variasi Konsentrasi Pemanis Aspartam Secara Granulasi Basah. CERATA Journal Of Pharmacy Science, 57-64. Gondo, H. K. (2021). Moringa Leaf Powder (Moringa oleifera) Decrease of Inflammation Plasma Cytokine of Pregnant Rats with Diabetes Mellitus. Open Access Macedonian Journal of Medical Sciences, 9(A), 1043-1046. Iwaszko, M., Biały, S., & Bogunia-Kubik, K. (2021). Significance of Interleukin (IL)-4 and IL�13 in Inflammatory Arthritis. Cells, 10(3000), 1-20. Jaja-Chimedza, A., Graf, B. L., Simmler, C., Kim, Y., Kuhn, P., Pauli, G. F., & Raskin, I. (2017). Biochemical Characterization and Anti-Inflammatory Properties of an Isothiocyanate-Enriched Moringa (Moringa Oleifera) Seed Extract. PLoS ONE, 12(8), 1– 22. Junttila, I.S. (2018). Tuning the Cytokine Responses: An Update on interleukin (iL)-4 and iL-13 Receptor Complexes. Medicine, 99(41), 1-8. Kemenkes. (2020). Tetap Produktif, Cegah, dan Atasi Diabetes Melitus. Jakarta: Infodatin-Pusat Data dan Informasi Kementrian Kesehatan. Kim, J.E., Jung, K., Kim, J.A., Kim, S.H., Park, H.S., & Kim, Y.S. (2019). Engineering of Anti�Human Interleukin-4 Receptor Alpha Antibodies with Potent Antagonistic Activity. Nature Scientific Report, 9(7772), 1-12. Liu, Z., Gong, J., Huang, W., Lu, F., & Dong, H. (2021). The Effect of Momordica charantia in the Treatment of Diabetes Mellitus: A Review. Hindawi: Evidence-Based Complementary and Alternative Medicine, 1-14. Modzelewski, R., Stefanowicz-Rutkowska, M.M., Matuszewski, W., & Bandurska-Stankiewicz, E.M. (2022). Gestational Diabetes Mellitus-Recent Literature Review. Journal of Clinical Medicine, 11(5736), 1-14. Oliveira, M.M., Andrade, K.F., Lima, G.H., & Rocha, T.C(2022). Metformin Versus Glyburide in Treatment and Control of Gestational Diabetes Mellitus: A Systematic Review with Meta-Analysis. Einstein Review, 20(eRW6155), 1-7. Plows, J.F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018). The Pathophysiology of Gestational Diabetes Mellitus. International journal of molecular sciences, 19(11), 3342. Plugis, N.M, Weng, N., Zhao, Q., Palanski, B.A., Maecker, H.T., Habtezion, A., & Khosla, C. (2018). Interleukin 4 is Inactivated via Selective Disulfide-Bond Reduction By Extracellular Thioredoxin. PNAS, 115(35), 8781–8786. Richter, D., Moraga, I., Winkelmann, H., Birkholz, O., Wilmes, S., Schulte, M, Kraich, M., Kenneweg, H., Beutel, O., Selenschik, P., Paterok, D., Gavutis, M., Schmidt, T., Garcia, K.C., Muller, T.D., & Piehler, J. (2017). Ligand-Induced Type II Interleukin-4 Receptor Dimers are Sustained by Rapid Re-Association Within Plasma Membrane Microcompartments. Nature Communication, 8(15976), 1-15. Rossalia, A.S.A.P. (2020). Jahe Sebagai Antiinflamasi. Jurnal Penelitian Perawat Profesional, 2(3), 309-316. Song, X., Chen, L., Zhang, S., Liu, Y., Wei, J., Wang, T., & Qin, J. (2022). Gestational Diabetes Mellitus and High Triglyceride Levels Mediate the Association between Pre-Pregnancy Overweight/Obesity and Macrosomia: A Prospective Cohort Study in Central China. Nutrients, 14(3347), 1-13. Teresa L. W., Heda M. D. N., M. Nurhalim S. (2011). Aspek Patobiologis pada Penyakit Trofoblas Gestasional. JKM, 10(2), 191-205. Wang, P., Wu, C.S., Li, C.Y., Yang, C.P., & Lu, M.C. (2020). Seasonality oGestational Diabetes Mellitus and Maternal Blood Glucose Levels: Evidence from Taiwan. Medicine, 99(e22684), 1-8. William B., Evi K., Syazili M., (2018). Potensi Ekstrak Buah Pare (Momordhica charantia) Sebagai Penurun Kadar Glukosa Darah: Manfaat Di Balik Rasa Pahit. Majority, 7(2), 177-181. Xu, B., Li, Z., Zeng, T., Wang, S., Ho, C., & Li, S. (2022). Bioactives of Momordica charantia as Potential Anti-Diabetic/Hypoglycemic Agents. Molecules, 27(2175), 1-17. Zhu, J. (2015). T Helper 2 (Th2) Cell Differentiation, Type 2 Innate Lymphoid Cell (ILC2) Development and Regulation of Interleukin-4 (IL-4) and IL-13 Production. Cytokine, 75, 14–24. Burton, G.J, & Jauniaux, E. (2015). What is the placenta? Am J Obstet Gynecol, 213(4): 6-8. Kapila, V., & Chaudhry, K. (2023). Physiology, Placenta. Treasure Island (FL): StatPearls Publishing. Okae, H., Toh, H., Sato, T., Hiura, H., Takahashi, S., Shirane, K., Kabayama, Y., Suyama, M., Sasaki, H., Arima, T. (2018). Derivation of Human Trophoblast Stem Cells. Cell Stem Cell Article, 22: 50–63. Parawansah., Wahyuni., Mahmudah, Z. (2016). Uji Efek Antipiretik dan Antiinflamasi Ekstrak Etanol Buah Pare (Momordica charantia L.) terhadap Mencit Jantan. Media Neliti, 4(1): 309-315. Rahmawati, Widiastuti, H., Sulistya, E. (2020). In Vitro Anti-Inflammatory Assay of Bitter Melon (Momordica charantia L.) Ethanol Extract. Jurnal Fitofarmaka Indonesia, 7(3): 1- 4. Valent, A.M., Choi, H., Kolahi, K.S., Thornburg, K.L. (2021). Hyperglycemia and gestational diabetes suppress placental glycolysis and mitochondrial function and alter lipid processing. The FASEB Journal, 35: 1-14
| Item Type: | Thesis (Bachelor (S1)) |
|---|---|
| Uncontrolled Keywords: | DAFTAR PUSTAKA Alif Z., Hermanto TJ, Widijati. (2018). Pengaruh Insulin, Jahe, Dan Kombinasi Keduanya Terhadap Jumlah Sel Trofoblasrattus Norvegicusmodel Diabetespragestasional. Qanun Medika, 2(1), 21-28. Al-Musawi, J.F.H. (2022). The Efficacy of Momordica Charantia L. (Herbal Agent) in Treatment of Type 1 Diabetes Mellitus in Rats in Comparison to Insulin (Animal Model). International Journal of Health Sciences, 6(S3), 6061-6070. Bare, Y., Kuki, A. D., Rophi, A. H., Krisnamurti, G. C., Lorenza, M. R. W. G., & Sari, D. R. T. (2019). Prediksi Asam Kuinat sebagai Anti-inflamasi terhadap COX-2 secara Virtual. Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati, 4(3), 124-129. Cheng, D., Gao, L., Su, S., Sargsyan, D., Wu, R., Raskin, I., & Kong, A. N. (2019). Moringa isothiocyanate activates Nrf2: potential role in diabetic nephropathy. The AAPS journal, 21(2), 1-14. Dawood, A.S., & Hussein, N. (2022). Evaluation of the Role of Interleukin-4 with Doppler Studies in Pregnancy Induced Hypertension and Its relation to Fetal Outcome. GinPolMedProject, 3(63), 1-5. Firdaus, Rimbawan, Sri Anna M., Katrin R., (2016). Model Tikus Diabetes yang Diinduksi Sreptozotocin-Sukrosa untuk Pendekatan Penelitian Diabetes Melitus Gestasional. Jurnal MKMI, 12(1). 29-34. Fitri, A., Sunyoto, & Nurul H., (2016). Uji Sifat Fisik Formulasi Tablet Anti Diabetes Ekstrak Pare (Momordica Charantia L.) Dengan Variasi Konsentrasi Pemanis Aspartam Secara Granulasi Basah. CERATA Journal Of Pharmacy Science, 57-64. Gondo, H. K. (2021). Moringa Leaf Powder (Moringa oleifera) Decrease of Inflammation Plasma Cytokine of Pregnant Rats with Diabetes Mellitus. Open Access Macedonian Journal of Medical Sciences, 9(A), 1043-1046. Iwaszko, M., Biały, S., & Bogunia-Kubik, K. (2021). Significance of Interleukin (IL)-4 and IL�13 in Inflammatory Arthritis. Cells, 10(3000), 1-20. Jaja-Chimedza, A., Graf, B. L., Simmler, C., Kim, Y., Kuhn, P., Pauli, G. F., & Raskin, I. (2017). Biochemical Characterization and Anti-Inflammatory Properties of an Isothiocyanate-Enriched Moringa (Moringa Oleifera) Seed Extract. PLoS ONE, 12(8), 1– 22. Junttila, I.S. (2018). Tuning the Cytokine Responses: An Update on interleukin (iL)-4 and iL-13 Receptor Complexes. Medicine, 99(41), 1-8. Kemenkes. (2020). Tetap Produktif, Cegah, dan Atasi Diabetes Melitus. Jakarta: Infodatin-Pusat Data dan Informasi Kementrian Kesehatan. Kim, J.E., Jung, K., Kim, J.A., Kim, S.H., Park, H.S., & Kim, Y.S. (2019). Engineering of Anti�Human Interleukin-4 Receptor Alpha Antibodies with Potent Antagonistic Activity. Nature Scientific Report, 9(7772), 1-12. Liu, Z., Gong, J., Huang, W., Lu, F., & Dong, H. (2021). The Effect of Momordica charantia in the Treatment of Diabetes Mellitus: A Review. Hindawi: Evidence-Based Complementary and Alternative Medicine, 1-14. Modzelewski, R., Stefanowicz-Rutkowska, M.M., Matuszewski, W., & Bandurska-Stankiewicz, E.M. (2022). Gestational Diabetes Mellitus-Recent Literature Review. Journal of Clinical Medicine, 11(5736), 1-14. Oliveira, M.M., Andrade, K.F., Lima, G.H., & Rocha, T.C(2022). Metformin Versus Glyburide in Treatment and Control of Gestational Diabetes Mellitus: A Systematic Review with Meta-Analysis. Einstein Review, 20(eRW6155), 1-7. Plows, J.F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018). The Pathophysiology of Gestational Diabetes Mellitus. International journal of molecular sciences, 19(11), 3342. Plugis, N.M, Weng, N., Zhao, Q., Palanski, B.A., Maecker, H.T., Habtezion, A., & Khosla, C. (2018). Interleukin 4 is Inactivated via Selective Disulfide-Bond Reduction By Extracellular Thioredoxin. PNAS, 115(35), 8781–8786. Richter, D., Moraga, I., Winkelmann, H., Birkholz, O., Wilmes, S., Schulte, M, Kraich, M., Kenneweg, H., Beutel, O., Selenschik, P., Paterok, D., Gavutis, M., Schmidt, T., Garcia, K.C., Muller, T.D., & Piehler, J. (2017). Ligand-Induced Type II Interleukin-4 Receptor Dimers are Sustained by Rapid Re-Association Within Plasma Membrane Microcompartments. Nature Communication, 8(15976), 1-15. Rossalia, A.S.A.P. (2020). Jahe Sebagai Antiinflamasi. Jurnal Penelitian Perawat Profesional, 2(3), 309-316. Song, X., Chen, L., Zhang, S., Liu, Y., Wei, J., Wang, T., & Qin, J. (2022). Gestational Diabetes Mellitus and High Triglyceride Levels Mediate the Association between Pre-Pregnancy Overweight/Obesity and Macrosomia: A Prospective Cohort Study in Central China. Nutrients, 14(3347), 1-13. Teresa L. W., Heda M. D. N., M. Nurhalim S. (2011). Aspek Patobiologis pada Penyakit Trofoblas Gestasional. JKM, 10(2), 191-205. Wang, P., Wu, C.S., Li, C.Y., Yang, C.P., & Lu, M.C. (2020). Seasonality oGestational Diabetes Mellitus and Maternal Blood Glucose Levels: Evidence from Taiwan. Medicine, 99(e22684), 1-8. William B., Evi K., Syazili M., (2018). Potensi Ekstrak Buah Pare (Momordhica charantia) Sebagai Penurun Kadar Glukosa Darah: Manfaat Di Balik Rasa Pahit. Majority, 7(2), 177-181. Xu, B., Li, Z., Zeng, T., Wang, S., Ho, C., & Li, S. (2022). Bioactives of Momordica charantia as Potential Anti-Diabetic/Hypoglycemic Agents. Molecules, 27(2175), 1-17. Zhu, J. (2015). T Helper 2 (Th2) Cell Differentiation, Type 2 Innate Lymphoid Cell (ILC2) Development and Regulation of Interleukin-4 (IL-4) and IL-13 Production. Cytokine, 75, 14–24. Burton, G.J, & Jauniaux, E. (2015). What is the placenta? Am J Obstet Gynecol, 213(4): 6-8. Kapila, V., & Chaudhry, K. (2023). Physiology, Placenta. Treasure Island (FL): StatPearls Publishing. Okae, H., Toh, H., Sato, T., Hiura, H., Takahashi, S., Shirane, K., Kabayama, Y., Suyama, M., Sasaki, H., Arima, T. (2018). Derivation of Human Trophoblast Stem Cells. Cell Stem Cell Article, 22: 50–63. Parawansah., Wahyuni., Mahmudah, Z. (2016). Uji Efek Antipiretik dan Antiinflamasi Ekstrak Etanol Buah Pare (Momordica charantia L.) terhadap Mencit Jantan. Media Neliti, 4(1): 309-315. Rahmawati, Widiastuti, H., Sulistya, E. (2020). In Vitro Anti-Inflammatory Assay of Bitter Melon (Momordica charantia L.) Ethanol Extract. Jurnal Fitofarmaka Indonesia, 7(3): 1- 4. Valent, A.M., Choi, H., Kolahi, K.S., Thornburg, K.L. (2021). Hyperglycemia and gestational diabetes suppress placental glycolysis and mitochondrial function and alter lipid processing. The FASEB Journal, 35: 1-14 |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RK Dentistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine > Medicine Study Program |
| Depositing User: | Ni Luh Putu Previa Niti Apsari |
| Date Deposited: | 13 Jun 2023 03:04 |
| Last Modified: | 13 Jun 2023 03:04 |
| URI: | http://erepository.uwks.ac.id/id/eprint/14768 |
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