The implications of multipotent mesenchymal stromal cells in tumor biology and therapy

Hernanda, Pratika Yuhyi (2016) The implications of multipotent mesenchymal stromal cells in tumor biology and therapy. Wiley-Blackwell. (Unpublished)

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Multipotent mesenchymal stromal cells (MSCs) are able to differentiate in vitro into adipocytes, osteoblasts and chondrocytes and into bone in vivo. MSCs have nowbeen isolated from multiple organs and they form part of the endothelial wall of blood vessels. In addition, they are a key component of tumor stroma and have been found to play important roles in various cancers. Tumors, having many of the characteristics of injured tissue, may attract MSCs from their local tissue or from the circulation. The tumor tropism property of MSCs has suggested the possibility of their use as vehiclesto deliver anticancer drugs or genes. However, extensive experimental research has demonstrated both anti- and procancer roles of MSCs in a context ­dependent manner. It is now generally assumed that within this microenvironment reciprocal tumor–stroma crosstalk influences the phenotype of tumor cells, their progression, and their metastasis. Various studies have reported the tumor-promoting effects of MSCs. Others have provided evidence for an antioncogenic role of these cells. MSCs are emerging as vehicles for anticancer drug/gene delivery [7]. This chapter aims to dissect this observed discrepancy in different experimental settings of human cancer so as to provide possible guidance to the appropriateness of clinical applications.

Item Type: Other
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Medicine Study Program
Depositing User: Sulimin BP3
Date Deposited: 25 Mar 2021 04:35
Last Modified: 25 Mar 2021 04:35

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