Dual Effects of Mesenchymal Stem /Stromal Cell in Tumor Animal Models: A Systematic Review For Risk Management Therapy of Stem Cell in Cancer Patients

Hernanda, Pratika Yuhyi (2018) Dual Effects of Mesenchymal Stem /Stromal Cell in Tumor Animal Models: A Systematic Review For Risk Management Therapy of Stem Cell in Cancer Patients. Universitas Airlangga. (Unpublished)

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Abstract

Several studies have reported the Mesenchymal Stem Cell (MSC) MSC effects triggered tumor growth and several other studies reported evidence of anti-tumor role in MSC. .However, the direct anti-HCC effects of MSC have hardly been studied in patients, but have been extensively investigated in tumor animal models .We therefore performed a systematic review and meta-analysis of animal studies evaluating the effects of MSC on tumors, especially solid tumors. Method: We collected the relevant studies by searching ProQuest, PubMed Publisher, and GoogleScholar. Studies were included according to the following inclusion criteria: Mesenchymal Stem/Stromal Cell, tumor, and xenograft /animal study. A meta-analysis was performed for the outcome measures: tumor growth (inhibit or promote tumor growth), source of MSC used and phase of MSC delivery (co-culture/post tumorigenesis). The search resulted in 440 references, of which 53 could be included in the review.The study characteristics of the included studies varied considerably. All of the studies reported outcomes related to tumor growth. Of these 53 experiments, 28 (53%) showed a significant decrease of tumor growth and 25 (47%) experiments showed a significant increase of tumor growth. Conclusion MSC appears to have a dual effect in animal models, therefore we call for caution using MSC in tumor / cancer patients. There are variations in experimental condition and method. Although the intrinsic limitations of animal studies, this systematic review could provide an important reference for future preclinical animal trials and may give contribution for risk management therapy of stem cell in cancer patients. Keywords: Mesenchymal Stem/Stromal Cell, Tumor, Animal Study, Risk Management

Item Type:	Other
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	25 Mar 2021 04:30
Last Modified:	25 Mar 2021 04:30
URI:	http://erepository.uwks.ac.id/id/eprint/8527

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