Hubungan antara kadar sitokin Tnf- α dengan osteoporosis pada wanita postmenopause di posyandu lansia yang memeriksakan kepadatan tulang di Rs Mitra Keluarga

Triyuliani, Liya (2019) Hubungan antara kadar sitokin Tnf- α dengan osteoporosis pada wanita postmenopause di posyandu lansia yang memeriksakan kepadatan tulang di Rs Mitra Keluarga. Other thesis, Wijaya Kusuma University of Surabaya.

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Abstract

ABSTRAK Triyuliani, Liya. 2019. Hubungan antara Kadar Sitokin TNF- α dengan Kejadian Osteoporosis pada Wanita Postmenopause di Posyandu Lansia yang Memeriksakan Kepadatan Tulang di RS Mitra Keluarga Surabaya. Tugas Akhir, Fakultas Kedokteran Surabaya. Pembimbing: Sri Lestari Utami, S.Si., MKes. Osteoporosis atau disebut dengan keropos tulang merupakan penyakit kronik yang ditandai dengan pengurangan massa tulang yang disertai kemunduran mikroarsitektur tulang dan penurunan kualitas jaringan tulang yang dapat menimbulkan kerapuhan tulang. Keadaan ini memiliki resiko tinggi sebab tulang menjadi rapuh dan mudah retak hingga patah. Tujuan penelitian ini untuk mengetahui hubungan antara kadar sitokin TNF-α dengan osteoporosis pada wanita postmenopause dari posyandu lansia yang memeriksakan kepadatan tulang di RS Mitra Keluarga Surabaya. Penelitian ini merupakan penelitian observational dengan desain penelitian cross sectional atau potong lintang yang dilakukan di Tropical Disease Center Kampus C Universitas Airlangga Surabaya dengan rentang waktu selama 1 Minggu. Populasi dalam penelitian ini adalah wanita postmenopause dari Posyandu Lansia yang memeriksakan kepadatan tulang ke Rumah Sakit Mitra Keluarga Surabaya sebanyak 75 orang. Setelah dilakukan uji analisis statistik dengan uji Berdasarkan data analisis tersebut dengan menggunakan uji Pearson didapatkan nilai p = 0,024 yang berarti ada hubungan kadar sitokin TNF-α dengan osteoporosis pada wanita postmenopause di posyandu lansia yang memeriksakan kepadatan tulang di RS Mitra Keluarga Surabaya. Kesimpulan dalam penelitian ini semakin tinggi kadar sitokin TNF-α maka semakin meningkat risiko terjadinya osteoporosis. Kata kunci: kadar sitokin TNF-α, osteoporosis, postmenopause ABSTRACT Triyuliani, Liya. 2019. The Relationship Between Sitocin TNF-α Levels With Osteoporosis in postmenopausal women from the elderly posyandu who examined bone density In Mitra Keluarga Hospital Surabaya. Final Assignment, Medical Faculty of Wijaya Kusuma Surabaya University. Tutor: Sri Lestari Utami, S.Si., MKes. Osteoporosis or bone loss is a chronic disease characterized by a reduction in bone mass accompanied by a decline in bone microarchitecture and a decrease in the quality of bone tissue that can cause bone fragility. This situation is at high risk because the bones become brittle and easily crack until they break. The purpose of this study was to determine the relationship between levels of TNF-α cytokines and osteoporosis in postmenopausal women from the elderly posyandu who examined bone density in Mitra Keluarga Hospital Surabaya. This research was an observational study with a cross sectional or cross sectional study design conducted at the Tropical Dieses Center Campus C Airlangga University Surabaya with a span of 1 week. The population in this study were postmenopausal women from the elderly Posyandu who examined bone density to Mitra Keluarga Hospital Surabaya 2016 as many as 75 people. After testing the statistical analysis with the Spearmans rho test, the p value <0.05 means that there is a relationship between the levels of TNF-α cytokines and osteoporosis in Javanese postmenopausal women from the elderly posyandu who examined bone density In Mitra Keluarga Hospital Surabaya. The conclusion in this study is that the higher levels of TNF-α cytokines, the higher the risk of osteoporosis. Keywords: levels of TNF-α cytokines, osteoporosis, postmenopause

Item Type:	Thesis (Other)
Uncontrolled Keywords:	kadar sitokin TNF-α, osteoporosis, postmenopause
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Liya Triyuliani
Date Deposited:	19 Aug 2019 07:13
Last Modified:	19 Aug 2019 07:13
URI:	http://erepository.uwks.ac.id/id/eprint/4027

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