The Effect of Phycocyanin on Caspase-3 Trophoblast Cells Models in Rats Preeclampsia Inducible Interleukin 6 (IL-6)

Gondo, Harry Kurniawan and Sardjono, T W and Kusworini, . (2017) The Effect of Phycocyanin on Caspase-3 Trophoblast Cells Models in Rats Preeclampsia Inducible Interleukin 6 (IL-6). Journal of Applied Environmental and Biological Sciences, 7 (4). pp. 210-213. ISSN 2090-4274

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Abstract

Preeclampsia is a pregnancy pathological condition characterized by increased blood tekananan and the occurrence of Uriah protein, which can be caused by inadequate trophoblast invasion and spiral arteries remodeling failure will be the cause of death Fetomaternal. In preeclampsia increased IL-6 in the trophoblast cells that act as a pro-inflammatory mediator with a predominance of Th1 immunology. Interleukin-6 together with TGF beta 1 (Transforming Growth Factor - beta 1) through 3 STAT pathway stimulates increased secretion of IL-17. Increased levels of IL-17 will further induce apoptosis of endothelial tissue by activating caspase-3. Preeclampsia until now there has been no proper medical treatment, because preeclampsia many factors that can trigger. Several studies have proven Phycocyanin related properties have the effect imunoregulasi namely by stimulating various immune functions such as production of cytokines, chemokines and other anti-inflammatory mediators, the activity of NK cell, B cell antibody production and proliferation of T cells is a laboratory experimental study using research design posttest control group design with treatment by subject menggunankan pregnant rat model of preeclampsia induced by IL-6. A total of 30 female rats. Test Phycocyanin effects on pregnancy pathological models, divided by 6 treatment groups the negative control group, positive control treatment with induction of IL-6, the group P1, P2, P3, and P4 that coadministration treatment groups between Phycocyanin suspension doses 10; 20; 40; 80 ng / 100gram BB for 5 days. Caspase-3 examination conducted by immunofluorescence method by comparing the expression of Caspase-3 between the control group and the treatment group. In granting Phycocyanin treatment with different doses showed decreased levels of Caspase-3 obtained at the lowest dose use Phycocyanin of 40ng / 100gram BB rats (592.24 ± 19.40). Phycocyanin in its use for the treatment of preeclampsia needed further research, in vivo and clinical.

Item Type:	Article
Uncontrolled Keywords:	Rat Preeclampsia, trophoblast, Phycocyanin, Interleukin-6, caspase-3
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	19 Oct 2018 07:06
Last Modified:	19 Oct 2018 07:06
URI:	http://erepository.uwks.ac.id/id/eprint/2878

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