Kajian gambaran histopatologi hepar pada tikus putih (rattus norvegicus) yang diinduksi cisplatin dan ekstrak daun bangun-bangun (coleus amboinicus) dengan pewarnaan Mallory azan

Utomo, Dwi Bagus (2018) Kajian gambaran histopatologi hepar pada tikus putih (rattus norvegicus) yang diinduksi cisplatin dan ekstrak daun bangun-bangun (coleus amboinicus) dengan pewarnaan Mallory azan. Other thesis, Wijaya Kusuma Surabaya University.

Text skripsi FKH UWKS dwi bagus utomo 14820059.pdf Download (1MB)

Abstract

ABSTRACT This study aimed to assess the effects of Cisplatin induction and bangun-bangun leaf extract (Coleous amboinicus). A total of 18 rats were used for this study. The design used in this research was completely randomized design with 3 treatments and 6 repetitions. The treatments were P0 (control), P1 (induced by 7mg / kg body weight of cisplatin) on the fourth day itraperitonially, CMC Na1% suspension every day, and P2 (given 100mg/kg body weight of bangun-bangun leaf extracts up orally every day and on the fourth day induced by 7mg/kg body weight of cisplatin. Histopathology were using Mallory Azan staining method . The data was obtained and analyzed using the Kruskal wallis test. Then followed by the Mann Whitney test using SPSS version 20. The results of Kruskal Wallis test, congestion P = 0,002, hemorhagic P = 0,002, and vasculitis P = 0,003 had a significant value (significantly different P <0,05). Result of Mann Whitney Test test, Congestion P0 with P1 (P = 0,002) was significant, P0 with P2 (P = 0,005) was significant, and P1 with P2 (P = 0,092) was not significant. As for hemoraghi P0 with P1 (P = 0,001) was significant, P0 with P2 (P = 0.007) was significant, and P1 with P2 (P = 0,083) was not significant. While vasculitis P0 with P1 (P = 0,001) was significant, P0 with P2 (P = 0,138) was not significant, and P1 with P2 (P = 0,019) was significant. From all of the data, it was concluded that Cisplatin induction and bangun-bangun leaf extracts (Coleus amboinicus) had an effect on the histopathological picture of white rats (Rattus norvegicus) is liver with Mallory Azan staining method. The bangun-bangun leaf extract was not significant to reduce congestion and hemorhage damage. But it was significant to reduce vasculitis. Keywords : Liver, Cisplatin, Bangun-bangun Leaf Extract (Coleus amboinicus), Mallory Azan, White Mice (Rattus norvegicus).

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Hepar, Cisplatin, Ekstrak Daun Bangun-Bangun (Coleus amboinicus), Mallory Azan, Tikus putih (Rattus norvegicus).
Subjects:	R Medicine > RB Pathology
Divisions:	Faculty of Vetenary Medicine > Vetenary Education Study Program
Depositing User:	Dwi Bagus Utomo
Date Deposited:	21 Sep 2018 10:28
Last Modified:	21 Sep 2018 10:28
URI:	http://erepository.uwks.ac.id/id/eprint/2658

Actions (login required)

View Item

Downloads