Neurological Abnormalities in Congenital Rubella Syndrome and Possible Pathophysiology

SOEKANTO, AYLY (2022) Neurological Abnormalities in Congenital Rubella Syndrome and Possible Pathophysiology. Univ. Sebelas Maret. (Unpublished)

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Abstract

Background: Congenital rubella syndrome is a disease that is a relative severe health problem because it causes multiorgan disability. The purpose of the study was to describe the neurological abnormallities that occur in congenital rubella syndrome and its pathophysiology. Case Presentation: A descriptive study with the subjects of the study of infants and children with congenital rubella syndrome found in the private practice of pediatricians for 10 years aged 1-5 years with the most complaints of developmental and growth delays, recurrent seizures and behavioral disorders. most are first children with mothers without Measles, Mumps, and Rubella (MMR) vaccination. Inclusion criteria: infants and children with clinical manifestations of at least 2 of all major clinical signs (hearing loss, congenital cataracts and congenital heart defects) accompanied by evidence of infection in the form of rubella-specific serum IgM and a history of the mother experiencing infection during pregnancy as evidenced by IgG results and or IgM rubella antibodies. Results: 13 cases were obtained, 92.3% of the case population with multi-organ disability and only 1 case (7.69%) with neurological disorders alone. 84.6% of cases of neurological disability occurred as a result of infection in the 1st trimester. Conclusion: Neurological abnormalities were acquired in the entire study population and were mostly due to infections in the 1st trimester of pregnancy. Keywords: neurological abnormalities, congenital rubella syndrome

Item Type:	Other
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	05 Sep 2023 05:26
Last Modified:	05 Sep 2023 05:26
URI:	http://erepository.uwks.ac.id/id/eprint/15262

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