Antibiofilm Activity of Honey in Multispecies Pathogen

Masfufatun, . Antibiofilm Activity of Honey in Multispecies Pathogen. BILDUNG. (Unpublished)

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Abstract

uction The invention of antimicrobial agents is an important contribution to the improvement of life-threatening communicable disease therapy. However, as a result of the widespread use of these useful drugs, a slew of new resistance mechanisms has developed and spread rapidly among bacteria that cause disease. Antibiotics resistance becomes more commonly found than before for instance bacteria strains that cannot be killed by Methicillin, Vancomycin, and Carbapenem [1], [2]. Besides mutations or gene resistance acquisition, this resistance could be caused by the ability of the microorganisms to form biofilms on the tissues or medical devices [2]. Microorganisms’ biofilm is a complex protective mechanism structure in which microbes stick one to another to a surface. Theses aggregate cells are embedded within a slimy substance called extracellular polymeric substances (EPS) result in an increment of surface attachment ability, a higher population density, as well as pathogenicity improvement [3]. The protective effects of biofilm formation from antimicrobial agents include decreased penetration, drug molecules trap in the extracellular matrix and higher concentration microbial inactivation enzymes [4]. The Biofilm formation may cause microorganisms become more difficult to eradicate from the host due to higher tolerance to standard antimicrobial drugs and also resistance to phagocytosis [5]. Moreover, in the form of biofilms, particular fungi such as Candida albicansis able to produce 2.3 times higher concentration of carcinogenic compounds such as acetaldehyde [6]. To overcome this problem, it is necessary to find better alternative treatment strategies to prevent, mitigate and destroy biofilms.

Item Type:	Other
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	28 Jul 2023 12:19
Last Modified:	28 Jul 2023 12:19
URI:	http://erepository.uwks.ac.id/id/eprint/15042

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