The Relationship Between Hormonal Contraception and Ovarian Cancer

Pertiwi, Ni kadek Sukma Apti (2023) The Relationship Between Hormonal Contraception and Ovarian Cancer. Bachelor (S1) thesis, Wijaya Kusuma Surabaya University.

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Abstract

Kanker ovarium merupakan salah satu kanker ginekologi yang memiliki angka mortalitas tertinggi. Gejala awal kanker ovarium tidak khas dan diagnosis biasanya ditegakkan dalam fase lanjut dengan survival rate yang rendah. Diduga patogenesis kanker ovarium berkaitan dengan ovulasi sebagai faktor risiko dan dapat dikendalikan dengan penggunaan kontrasepsi hormonal. Tujuan Penelitian ini adalah untuk mengetahui keterkaitan penggunaan kontrasepsi hormonal terhadap kejadian kanker ovarium. Penelitian ini merupakan jenis penelitian literatur review sistematik. Metode tersebut menganalisis berbagai literatur dari Internet dengan pencarian jurnal di Proquest, PubMed, Google scholar, serta jurnal dengan topik kontrasepsi hormonal, kanker ovarium dan keterkaitan kontrasepsi hormonal dan kanker ovarium. Kemudian menarik kesimpulan dengan mengelompokkan teori dan data. Pada penelitian ini menggunakan 53 artikel dari tahun terbit 2011-2022 dengan mendata karakteristik artikel penelitian yang berisi author, tahun, judul, dan hasil penelitian berupa p- value, OR dan 95% CI. Dari hasil analisis yang dilakukan didapatkan bahwa penggunaan kontrasepsi hormonal kombinasi (progestin dan estrogen) menunjukkan nilai rata – rata OR=0,70 serta rentang 95% CI=0,46-1,15, penggunaan kontrasepsi hormonal progestin menunjukan nilai rata – rata OR= 0,70 serta rentang 95% CI = 0,35-1,40 menurunkan risiko kanker ovarium. Kata kunci: Kanker Ovarium ; Kontrasepsi Hormonal Ovarian cancer is one of the gynecological cancers that has the highest mortality rate. The early symptoms of ovarian cancer are not typical and the diagnosis is usually made in an advanced phase with a low survival rate. It is suspected that the pathogenesis of ovarian cancer is related to ovulation as a risk factor and can be controlled by the use of hormonal contraception. The purpose of this study was to determine the relationship between the use of hormonal contraception on the incidence of ovarian cancer. This research is a type of systematic review literature research. This method analyzes various literatures from the Internet by searching journals in Proquest, PubMed, Google scholar, as well as journals on the topic of hormonal contraception, ovarian cancer and the relationship between hormonal contraception and ovarian cancer. Then draw conclusions by grouping theory and data. In this study, 53 articles were published from 2011-2022 by collecting data on the characteristics of research articles containing author, year, title, and research results in the form of p-value, OR and 95% CI. From the results of the analysis, it was found that the use of combined hormonal contraceptives (progestin and estrogen) showed an average value of OR = 0.70 and a 95% CI = 0.46-1.15 range, the use of progestin hormonal contraceptives showed an average OR value. = 0.70 and the 95% CI range = 0.35-1.40 reduced the risk of ovarian cancer. Keywords: Ovarian Cancer; Hormonal Contraception

Item Type: Thesis (Bachelor (S1))
Uncontrolled Keywords: Kanker Ovarium ; Kontrasepsi Hormonal, Ovarian Cancer; Hormonal Contraception
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Medicine Study Program
Depositing User: Ni Kadek Sukma Apti Pertiwi -
Date Deposited: 12 Apr 2023 06:33
Last Modified: 12 Apr 2023 06:33
URI: http://erepository.uwks.ac.id/id/eprint/13808

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