The Effect of Spirulina on Apoptosis Through the Caspase-3 Pathway in a Preeclamptic Wistar Rat Mode

Gondo, Harry Kurniawan (2021) The Effect of Spirulina on Apoptosis Through the Caspase-3 Pathway in a Preeclamptic Wistar Rat Mode. Published by Wolters Kluwer – Medknow-India. (Unpublished)

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Abstract

Abstract Objective: To determine the effects of spirulina expression on trophoblast cell apoptosis and caspase-3 expression in a preeclamptic wistar rat model. The preeclampsia model was administered to pregnant rats by interleukin-6 induction. Materials and Methods: This research is a Post Test Only Control Group Design. A total of 25 rats with preeclampsia model were divided into five groups, namely negative control group, positive control group, treatment group with IL-6 administration, and spirulina with 10 mg, 20 mg, and 40 mg/100 g body weight. Research has shown that spirulina reduces trophoblast cell expression through apoptosis in a rat model of preeclampsia. The positive control group showed the highest mean expression of apoptosis (62.38) and caspase-3 (804.33. The lowest average expression of apoptosis was 44.26, with 592.24 expressions of caspase-3 in group P3, Spirulina treatment at a dose of 40mg/day /kgBW Conclusion: Spirulina inhibits trophoblast apoptosis in preeclampsia through caspase-3 signaling. Keywords: Apoptosis, caspase-3, interleukin-6, preeclampsia, spirulina, trophoblast.

Item Type:	Other
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Medicine Study Program
Depositing User:	Sulimin BP3
Date Deposited:	13 Dec 2021 06:33
Last Modified:	13 Dec 2021 06:33
URI:	http://erepository.uwks.ac.id/id/eprint/10610

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